| 14/11/2021 00:00 | | Macara Reserves  | 4 - 3 | Independiente del Valle Reserves | T |
| 17/10/2021 22:00 | | Macara Reserves | 1 - 1 | Universidad Catolica del Ecuador Reserves | H |
| 18/09/2021 22:30 | | Macara Reserves | 2 - 0 | Guayaquil City Reserves | T |
| 04/09/2021 22:00 | | Macara Reserves | 5 - 0 | Tecnico Universitario Reserves | T |
| 13/08/2021 22:13 | | Macara Reserves | 1 - 1 | Independiente del Valle Reserves | H |
| 16/07/2021 23:30 | | Tecnico Universitario Reserves | 0 - 1 | Macara Reserves | T |
| 10/07/2021 02:00 | | Macara Reserves | 0 - 1 | Universidad Catolica del Ecuador Reserves | B |
| 03/07/2021 22:00 | | Macara Reserves | 2 - 1 | Olmedo Reserves | T |
| 18/06/2021 22:15 | | Macara Reserves | 2 - 2 | SD Aucas Reserves | H |
Ecuador