| 19/11/2021 22:00 | | Universidad Catolica del Ecuador Reserves  | 2 - 2 | Emelec Reserves | H |
| 14/11/2021 22:00 | | Universidad Catolica del Ecuador Reserves | 1 - 0 | Club 9 de Octubre (R) | T |
| 17/10/2021 22:00 | | Macara Reserves | 1 - 1 | Universidad Catolica del Ecuador Reserves | H |
| 09/10/2021 00:10 | | Universidad Catolica del Ecuador Reserves | 3 - 2 | LDU Quito Reserves | T |
| 18/09/2021 00:00 | | Universidad Catolica del Ecuador Reserves | 1 - 1 | Orense Reserves | H |
| 06/08/2021 22:00 | | Mushuc Runa Reserves | 0 - 2 | Universidad Catolica del Ecuador Reserves | T |
| 23/07/2021 23:30 | | Tecnico Universitario Reserves | 0 - 2 | Universidad Catolica del Ecuador Reserves | T |
| 10/07/2021 02:00 | | Macara Reserves | 0 - 1 | Universidad Catolica del Ecuador Reserves | T |
Ecuador